注册用户2590位
用户名: 密码:   注册
 
首页 >> 精彩文章Journal Club

GATA3 Immunohistochemistry for Distinguishing Sarcomatoid and Desmoplastic Mesothelioma From Sarcomatoid Carcinoma of the Lung

发布日期:2018/2/7 22:55:56 文章来源: 作者: 点击次数:5186

 

Journal Club 幻灯(点击打开)

 

Am J Surg Pathol  Volume 41, Number 9, Sep 2017:1221–1225

GATA3 Immunohistochemistry for Distinguishing Sarcomatoid and Desmoplastic Mesothelioma From Sarcomatoid Carcinoma of the Lung

Kyra B. Berg, MD* and Andrew Churg, MD*†

From the *Department of Pathology, University of British Columbia;and †Department of Pathology, Vancouver General Hospital, Vancouver,BC, Canada.

Abstract: The separation of sarcomatoid and desmoplastic malignant mesotheliomas from sarcomatoid carcinomas of the lung metastatic to the pleura may be difficult, since both types of tumor can be morphologically similar and are frequently positive only for pan-keratin. GATA binding protein 3 (GATA3) is most commonly used as an immunohistochemical marker of breast and urothelial carcinoma, but is also known to stain other types of tumors including some mesotheliomas. In this study we asked whether GATA3 stains could be used to distinguish sarcomatoid/desmoplastic malignant mesotheliomas (N=19) from sarcomatoid carcinomas of the lung (N=13). Tumor staining was scored for diffuseness and intensity, with a maximum possible score of 6. All 19 sarcomatoid/desmoplastic malignant mesotheliomas examined showed strong diffuse staining for GATA3 (no case scored <3, mean score±SD for all 19 cases5.4±0.9), whereas only 2 of 13 sarcomatoid carcinomas of the lung stained positively for GATA3 and the staining was weak and patchy (score 2 for each case, mean±SD for all 13 cases 0.4±0.8). There was no correlation between the intensity and diffuseness of GATA-3 staining and staining for traditional mesothelioma markers. Overall, any positive staining for GATA3 was 100% sensitive and 85% specific for sarcomatoid/desmoplastic mesothelioma. We conclude that strong diffuse staining for GATA3 favors a diagnosis of sarcomatoid/desmoplastic malignant mesothelioma over metastatic sarcomatoid carcinoma of the lung; conversely, complete absence of GATA-3 staining is evidence against a diagnosis of sarcomatoid/desmoplastic malignant mesothelioma.

 

 

GATA3免疫组化鉴别肉瘤样和促结缔组织增生性间皮瘤与肺的肉瘤样癌

摘要:将肉瘤样和促结缔组织增生性恶性间皮瘤与转移到胸膜的肉瘤样癌区分开可能很困难,因为这两种类型的肿瘤形态相似且常仅广谱角蛋白阳性。GATA3是乳腺癌和尿路上皮癌最常用的免疫组化标记,但也表达于其他肿瘤包括一些间皮瘤。在这项研究中,我们想知道GATA3是否可以用于鉴别肉瘤样/促结缔组织增生性恶性间皮瘤(n = 19)与肺的肉瘤样癌(n = 13)。肿瘤染色用强度和范围进行评分,最高分为6分。19例肉瘤样/促结缔组织增生性恶性间皮瘤GATA3全部呈弥漫且强阳性表达(没有病例评分<319例的平均评分为5.4±0.9),而肺的肉瘤样癌13例中只有2例局部弱表达(两例评分均为213例的平均评分为0.4±0.8)GATA3表达的强度和面积与传统间皮瘤标记无相关性。总的来说,GATA3在肉瘤样/促结缔组织增生性间皮瘤中的敏感性可达100%,特异性为85%。我们的结论是GATA3强而弥漫性表达支持肉瘤样/促结缔组织增生性恶性间皮瘤的诊断,而非肺的肉瘤样癌;反之,GATA-3完全阴性则不支持肉瘤样/促结缔组织增生性恶性间皮瘤。(翻译 付欣)

上一篇:关于开展中青年病理医师英语演讲比赛活动的通知
下一篇:Recommendations for reporting tumor budding in colorectal cancer based on the International Tumor Budding Consensus Conference (ITBCC) 2016
相关评论
Email: 账号:
相关文章
同类最热文章
    最新文章
· 关于开展第二届中青年病理医师
· 广东省粤港澳合作促进会医药卫
· 中华医学会病理学分会下基层系
· 首届中国病理住院医师规培工作
· 基层病理培训班玉林站顺利举办
· 中华医学会病理学分会基层病理
· 第一届中青年病理医师英语演讲
· 江苏省物价局、省卫生和计划生
· 第八届中国病理年会之病理技术
· 为何规范与推广肺癌小样本取材
    最新读片
· Journal club 20180328
· Journal Club 20180314
· Journal Club 20180307
· Journal Club 20171025
· Journal Club 20171108
· Journal Club 20171213
· Journal Club 20171018
· Journal Club 20171011
· Journal Club 20170906
· Journal Club 20170704
· Journal Club 20170830
· Journal Club 20170628


地 址:北京市东城区东四西大街42号·中华医学会 邮 编:100710
版权所有: 中华医学会病理学分会版权所有 CSP All CopyRights Reserved 2011-2012
免责条款|京ICP备08000766号 访问量: