刘冲, 徐金峰, 安晓静, 石群立, 刘琦, 周航波, 马恒辉
The research of of retinoic acid receptor（RARα&RXRα）in Ovarian Carcinoma:expression and prognosis
Liu Chong,Xu Jinfeng,An Xiaojing,Shi Qunli,Liu Qi,Zhou Hangbo,Ma Henghui
Department of Pathology, Nanjing University Medical College/Nanjing General Hospital of Nanjing Command, Nanjing, Jiangsu, 210002, China.
Objective To investigate the retinoic acid receptor RARα and RXRα expression in ovarian cancer and its relationship with clinicopathological parameters and prognosis.Method 93 cases of primarily ovarian cancer tissue samples was determined by immunohistochemistry and analyze significance of expression both RARα and RXRα. Discuss the significance of expression of RXRα and RARα with clinical of pathological parameters by pearson χ2 test .Use non-parametric spearman correlation coefficient between the two relevance.The follow-up results was studied by Cox survival analysis. Results In the 93 cases of ovarian cancer,the expression rates of RARα and RXRα were 68.8%, 52.7%. There were no significant of RARα expression with patient age, tumor size and metastasis (including lymph nodes) (P> 0.05), but with ovarian cancer tumor grade, histologic type and FIGO stage (p<0.05). There were no significant of RXRα expression with patient age, tumor size, histological type, FIGO stage and metastasis (P> 0.05), but with the pathological grading ovarian cancer (p <0.05). The spearman correlation coefficient test was showed that RARα and RXRα expression in ovarian cancer was positively correlated (r = 0.4432, P = 0.000), both coordinated expression. In the whole cases with followed-up data ,Cox univariate analysis and multivariate analysis showed that FIGO stage and RARα expression were related to prognosis of patients with ovarian cancer, both are the factors affecting the prognosis of ovarian cancer (p <0.05). There were no relationship with age, tumor size, histological type, histological grade to prognosis (P> 0.05).Conclusion High expression of RARα and RXRα were suggested highly malignant tumor. FIGO stage, RARα were closed to the prognosis of patients with ovarian cancer, especially test RARα expression may be an useful and effective biological indicator as diagnostic testing and assessment of prognosis of ovarian cancer patients.Retinoic acid receptor has an important role in the regulation of tumorigenesis, induction of differentiation, can be used as a target for ovarian cancer therapy.